Subhabrata Chaudhury

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Subhabrata Chaudhury, Ph.D., is an organic chemist. His research is focused on developing small molecule-based therapeutics for several diseases including cancer, diabetes, and Alzheimer's disease. He has developed several small molecule inhibitors that are selective for Hsp90-beta (Hsp90-β) isoform. Hsp90-β is a biological target in cancer chemotherapeutics. Chaudhury has also worked on the scalable synthesis of various small molecules that are potent and selective estrogen receptor-β (ERβ) agonists as potential drug candidates for depression, anxiety, and dementia associated with menopausal women. Some of these molecules are in pre-clinical trials. His industrial experience comes from working as a team leader (medicinal chemistry) in oncology and virology.

Chaudhury's training in organic synthesis was at the Indian Institute of Technology-Kharagpur (M.Sc.), and then at Marquette University (Ph.D.) as a student. He worked as a researcher in several institutes including the University of Kansas, the Medical College of Wisconsin, the University of Glasgow, and the University of Notre Dame. He was also a visiting assistant professor at Marquette University. Chaudhury serves as a peer reviewer for several chemistry and medicinal chemistry journals.

Recent Projects and Research

• Design, synthesis, and bio-evaluation of potent and selective small molecule modulators of pyruvate carboxylase (PC) enzyme as potential drug candidates for cancer and diabetes.
• Development of L-type amino acid transporter-1 (LAT-1) selective inhibitors as potential cancer drugs.
• Development of new cycloaddition methodologies using trimethylenemethane-transition metal complexes.

Selected Publications

• "Discovery of two novel (4-hydroxyphenyl) substituted polycyclic carbocycles as potent and selective estrogen receptor beta agonists" Wetzel, E. A; Marks, Gleason, A. A.; K. J., Brown-Ford, S.; Reid, T.; Chaudhury, S,; Lindeman, S.; Sem, D. S.; Donaldson, W. A. Bioorganic & Medicinal Chemistry Letters 2022, 73, 128906.
• "Structure-based design, synthesis and biological evaluation of Hsp90β-selective inhibitors" Chaudhury, S.; Meka, P. N,; Banerjee. M.; Blagg, B. S. J. Chemistry – A European J. 2021, 27, 14747–14764
• "The Role and Therapeutic Potential of Hsp90, Hsp70, and Smaller Heat Shock Proteins in Peripheral and Central Neuropathies" Chaudhury, S.; Keegan B. M; Blagg, B. S. J. Medicinal Research Reviews 2021, 41, 202–222
• "Reactivity of (3-Methylpentadienyl)iron(1+) Cation: Late-stage Introduction of a (3-Methyl-2Z,4-pentadien-1-yl) Side Chain" Chaudhury, S.; Li, S.; Donaldson, W. A. Mediterranean Journal of Chemistry 2016, 5, 540–547
• "Synthesis of the A-D ring system of the Gambieric Acids" Clark, S. J.; Romiti, F.; Sieng, B.; Paterson, L. C.; Stewart, A.; Chaudhury, S.; Farrugia, L. J. Organic Letters 2015, 17, 4694–4697.
• "Generation of molecular complexity from cyclooctatetraene using dienyliron and olefin metathesis methodology" El-Mansy, M. F.; Sar, A.; Chaudhury, S.; Wallock, N. J.; Donaldson, W. A. Organic & Biomolecular Chemistry 2012, 10, 4844–4846.
• "Recent Applications of Acyclic (Diene)iron Complexes and (Dienyl)iron Cations in Organic Synthesis" Donaldson, W. A.; Chaudhury, S. European Journal of Organic Chemistry 2009, 3831–3843.
• "Preparation, Characterization and Reactivity of (3-Methylpentadienyl)iron(+1) Cations" Chaudhury, S.; Li, S.; Bennett, D. W.; Siddiquee, T.; Haworth, D. T.; Donaldson, W. A. Organometallics 2007, 26, 5295–5303.
• "Generation of molecular complexity from cyclooctatetraene: synthesis of a protected 2-(3/-carboxy-2/-benzoylcyclopentyl)glycine" Chaudhury, S.; Lindeman, S.; Donaldson, W. A. Tetrahedron Letters 2007, 48, 7849–852.
• "Hsp90 as a target for drug development" Chaudhury, S.; Welch, T. R.; Blagg, B. S. J. ChemMedChem. 2006, 1, 1331–1340.
• "Synthetic studies directed towards the proposed structure for heteroscyphic acid A" Chaudhury, S.; Li. S.; Donaldson, W. A. Journal of Chemical Society, Chemical Communications 2006, 19, 2069–2070.
• "Crystal and molecular structure of bis(8-phenylmenthyl) 2-(2methyl-5-oxo-3-cyclohexen-1-yl)propionate, C42H54O5.CH3CN" Bennett, D. W.; Siddiquee, T.; Haworth, D. T.; Chaudhury, S.; Donaldson, W. A. Journal of Chemical Crystallography 2006, 36, 777–780.
• "Nucleophilic addition to (3-methylpentadienyl)iron(+1) cations: counterion control of regioselectivity; application to the enantioselective synthesis of 4,5-disubstituted cyclohexenones" Chaudhury, S.; Donaldson, W. A. Journal of American Chemical Society 2006, 128, 5984–5985.
• "Synthesis and reactivity of tricarbonyl(1-methoxycarbonyl-5-phenylpentadienyl)iron(1+)cation" Chaudhury, S.; Donaldson, W. A.; Bennett, D. W.; Haworth, D. T. Siddiquee, T. A; Kloss, J. M. Donaldson, W. A. Journal of Organometallic Chemistry 2004, 689, 1437–1443.

Courses Taught at New York Tech

• CHEM 210

Contact Info

• schaud21@nyit.edu